Free movement of the adhesive on the surface of the substrate means that it must overcome any surface tension effects present at the interface. The science of adhesion I. Despite a high molecular weight of 19,, for dextrans, they have adhesive strength similar to that of polyethylene glycol PEG , with a molecular weight of , Studies on novel mucoadhesive systems involve the use of multifunctional materials. Here, we are underlining several formulations which are in clinical trials or commercial products. Attraction and repulsion forces arise and, for a mucoadhesive to be successful, the attraction forces must dominate.

The mucous membrane is mounted in a compartment under physiological conditions and the microsphere is positioned directly below the magnetic probe. However, it is of value when the bioadhesive system is formulated as a patch. Local drug therapy is used to treat disease states like aphthous ulceration gingivitis, periodontal disease, and xerostoma. Rheological study on mucoadhesivity of some nasal powder formulations. Reinhart and Peppas[ 12 ] reported that the diffusion coefficient depended on the molecular weight of the polymer strand and that it decreased with increasing cross-linking density. The mucous site most used for drug administration and absorption is gastrointestinal Junginger, Thanou, Verhoef, , but other routes, including nasal, ocular, buccal, vaginal, rectal, oral, and periodontal have also been studied Bruschi et. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism.

Potential of photodynamic therapy in treatment of fungal infections of the mouth. An xystem method for buccal adhesion studies: Benzydamine, chitosan derivatives[ 57 ]. Eur J Pharm Biopharm.

Mucoadhesive drug delivery systems

Mucosal delivery of drugs via the buccal route is still very challenging in spite of extensive clinical studies. The polymer must not decompose on storage or during the shelf life of the dosage form. Bioadhesive hyaluronan-chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissue. Some hydrogels do not build liquid crystals but are able to gelify in situ after exposure to an external stimulus.


Mucoadhesive drug delivery systems

Electronic microscopy gives a larger view, but the environmental conditions in which the sample must be submitted are far from the physiological conditions. Ocular Mucoadhesive Drug Delivery Systems Drug administration to the eye is a challenge because there are several mechanisms tear production, tear flow, and blinking that protect the eye from the harmful agents. The evaluation of bioadhesive properties is fundamental to the development of novel bioadhesive delivery systems.

Surfactants and polymers in drug delivery. Thesks most commonly found lectins are those isolated from Abrus precatroius, Agaricus bisporus, Anguilla anguilla, Arachis hypogaea, Pandeiraea simplicifolia, and Bauhinia purpurea Chowdary, Rao, Adhesive topical drug delivery system. Therefore, several conventional drug delivery systems already in use can become bioadhesive after redesign erug including bioadhesive substances in their formulation. thesid

However, a wide variation in results is found in the literature that utilize rheological methods for mucoadhesion determination, which may be attributable to differences in mucin type and concentration,[ 3839 ] as well as polymer concentrations.

Molecular aspects of muco- and bioadhesion: Perioli[ 83 ] studied the influence of velivery force on tablet behavior and drug release rate for mucoadhesive buccal tablets.

Fracture and interpenetration analysis in poly acrylic acid -containing systems. Permeability thesia property of oral mucosa due to intercellular materials derived from membrane-coating granules.

Author demonstrated increased adhesion when water was limited in the system due to an increase in the elasticity, caused by the complex formation mucoadhesivd drug and the polymer.

This technique can provide information about the compatibility between mucus and mucoadhesive system by means of the evaluation of the movement of the charged particles.


mucoadhesive drug delivery system thesis

Mucin is the most important glycoprotein of mucus and is systdm for its structure. Details of the mucoadhesive dosage forms are given in Table 3. Thus mucosal drug delivery system could be of value in delivering a growing number of high-molecular-weight sensitive molecules such as peptide and oligonucleotides. Eur J Pharm Sci. This results in the establishment of the electrical double layer at the interface and a series of attractive forces responsible for maintaining contact between the two layers.

Mucoadhesive drug delivery systems

Above this region, the structure is destroyed. Based on results, a force-distance curve can be plotted which yields the force required to detach the mucin disc from the surface with the formulation Bruschi et delievry.

Fracture energy g c can be obtained from the reversible adhesion work, W r energy required to produce new fractured surfacesand the irreversible adhesion work, W i work of plastic deformation provoked by the removal of a proof tip until the disruption of the adhesive bondand both values are expressed as units of fracture surface A f. The latter polymer category includes lectins and thiolated polymers.

Solid micro- and nano-particulate systems based on chitosan and derivatives have been the focus of several deliveryy Bravo-Osuna et al. None of these mechanisms or theories alone can explain the mucoadhesion which occurs in an array of different situations. These groups allow hydrogen bonding with the substrate, swelling in aqueous media, thereby allowing maximal exposure of potential anchor sites. syste,

mucoadhesive drug delivery system thesis

Tablets can be applied to different regions of oral cavity, such as cheeks, lips, gums, and palate.