RENINOMA CASE REPORT AND LITERATURE REVIEW

AU – Haynes, Claudia M. As previously mentioned, kidney function was normal and there was no proteinuria or hematuria present. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis. On light microscopy, reninomas are composed of closely packed uniform, round to polyhedral cells with granular, eosinophilic cytoplasm. We present our approach to diagnostic evaluation of this patient that led us to the correct diagnosis of reninoma, and discuss the medical management and surgical treatment of this rare tumor. We achieved good blood pressure control with this combination of antihypertensives, and therefore continued with this treatment until the surgical removal of reninoma.

Dissection of the tumor with scissors A and the closure of the defect with interrupted mattress suture B. J Clin Invest 45 The vessels were dissected and clamped. There was no history of nausea, vomiting, syncope, or visual disturbance. Cytogenetic examination of the tumor revealed normal female karyotype 46, XX without any chromosomal abnormalities. The biochemical profile on the first blood sample after admission was normal, apart from mild hypokalemia 3. Ideally, the measurement of plasma and urine electrolytes is done before any treatment including intravenous fluid administration is instituted.

Neurological examination was normal.

reninoma case report and literature review

Similar articles Malignant hypertension due to a large reninoma: The causative gene s are, however, unknown at present. Fundoscopy was normal without any evidence literaure hypertensive changes. This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis.

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The changing face of pediatric hypertension in the era of the childhood obesity epidemic. CTA excluded RAS but revealed the small subcapsular tumor reninoma of the left kidney as a suspected cause of hypertension. reninomma

reninoma case report and literature review

The tumor was separated from the normal kidney parenchyma by an incomplete fibrous capsule Figure 4 A. N2 – Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin. Elevated blood levels rrninoma renin and aldosterone confirm the clinical suspicion of renin-mediated hypertension.

The next step in diagnostic evaluation of hypertensive patients presenting with hypokalemia and metabolic alkalosis is the measurement of renin and aldosterone blood levels to confirm renin-mediated hypertension.

Reninoma: Case report and literature review

The family history was significant for factor V Leiden deficiency in her father and migraines in her mother and two sisters. Contrast imaging studies and selective venous renin sampling might be helpful in identifying the source of excessive renin production. geninoma

reninoma case report and literature review

Pulses were well palpable in all limbs with no radio-femoral delay. A renin-secreting tumour with severe hypertension and cardiovascular disease: Further imaging studies were aimed at localizing the source of increased renin rsview.

The tumor cells were uniform with round nuclei and eosinophilic relort cytoplasm Figure 4 B. They all contributed to the writing of this manuscript and its revision.

The correct diagnosis is based on the combination of macroscopic appearance of rport tumor, light microscopy of the tumor cells, immunohistochemical staining for various cell markers including reninand typical ultrastructural finding of intracellular renin deposits 38. Warm ischemic times are usually less than 30 min with no cases of acute kidney injury reported in the literature.

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Reninoma of the left kidney.

Reninoma: case report and literature review. – PubMed – NCBI

literatude Pediatric case of the day. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Link to citation list in Scopus. Imaging of renin-mediated hypertension in children. Piterature studies suggest that the possible oncogene s or tumor suppressor gene s may be localized on chromosome 4 and 10, or chromosome 9 and 11, respectively 325 For patients with diminished renal function when the nephrotoxic effects of iodinated contrast may be amplified, as with gadolinium-based contrast for MRI, specific measures such as pre-hydration may be necessary.

Journal of Hypertension26 2 Pediatr Nephrol 28 7: Comparison of 1, laparoscopic and open partial nephrectomies for single renal tumors. Our patient presented with long-standing headaches, followed by the development of lethargy, and polyuria with polydipsia.

Reninoma: case report and literature review. – Semantic Scholar

Pediatr Pathol 13 4: Electron microscopy revealed renin deposits in the cytoplasm of the tumor cells, confirming the diagnosis of reninoma. Abstract Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin. Prominent thick and thin-walled vessels are usually present.

Pubmed Abstract Pubmed Full Text. We describe a case of reninoma and provide a review of the literature, with a discussion emphasizing the diagnostic evaluation for such patients.

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