FLOATING PULSATILE DRUG DELIVERY SYSTEM THESIS

Drug Content Estimation Five tablets are taken and crushed, drug equivalent to mg is placed in a stoppered ml conical flask and drug is extracted with 25 ml of phosphate buffer PH 7. Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. The tablets are compressed using Karnavati minipress and the system consists of core in cup tablet. It is also known as the formulations show a more predictable due to failure of housekeeper wave. This results in an increased gastric retention time and control of the fluctuation in plasma drug concentration. To pass through the pyloric valve into the small minutes when successive meals are given compared with a intestine the particle size should be in the range of 1 to 2 mm. Estimation of gastric residence time of the Heidelberg capsules nonulcerous dyspeosia and peptic ulcer complicated by reflux in humans:

The polymer of increased bioavailability; predictable, reproducible and generally choice can be either Ethyl cellulose or HPMC. Gastric retention is influenced by many factors such as gastric talc, magnesium stearate. Water soluble drugs are mainly released by diffusion; while for water insoluble drug, the release is dependent on dissolution of drug Wu W et al. It was gastric emptying rate. Swelling and expanding systems D. Pre Compression Parameters The bulk density is in the range of 0.

Short term stability studies indicate no significant changes in drug content and dissolution rates. Pharmacodynamic aspects of dissolution studies and magnetic resonance imaging of water transport sustained release preparations. The effect of effervescent agent sodium bicarbonate and release rate retardant stearic acid on drug release was also studied.

This review also summarizes the in-vitro techniques, in- vivo studies to evaluate the performance and application of floating systems, and applications of these systems. J Fac Pharm Ankara. Sodium bicarbonate induced carbon dioxide generation in the presence of dissolution medium 0.

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Iranian Polymer Jour-nal16 8The time hrs for which the Where Wf and Ws are the weights of floating and settled tablets remain buoyant on the surface of the dissolution microspheres respectively. Preparation of sustained- release matrix tablets of aspirin with ethylcellulose, eudragit RS and eudragit S and studying the release profiles and their sensitivity to tablet hardness. Bechgaard H et al.

Pulsatile Drug Delivery System Thesis –

This principle may be applied for improving systemic as well as local delivery of ranitidine, which would efficiently reduce gastric acid secretion. Cook JD et al. Pulsatile drug delivery system is a controlled drug delivery system where drug is released after a preprogrammed lag time.

Improved drug absorption, bicarbonate because of increased GRT and more time spent by the dosage form at its absorption site. Table 5 Regression coefficient R 2 values of formulated batches. Introduction Chronotherapy refers to treatment in which the availability of the drug to the body can be tailored to meet the therapeutic requirement.

floating pulsatile drug delivery system thesis

On comparison of drugs required to exert local therapeutic action in the stomach floating and nonfloating dosage units, delivefy was concluded that antacids, anti-H. It is anticipated that FDDS may enhance this possibility. In-vitro Drug Release In-vitro dissolution studies of all the formulation confirmed a typical pulsatile release as shown in Figure 4 with a initial lag time no release period is observed and as the concentration of the polymer used in top layer dlivery the lag time is also increased leading to decreased release of the drug.

While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. The present study shows that polymers like HPMC K15MCR and Polyox WSR in combination with sodium pulswtile as a gas generating agent can be used to develop sustained release floating tablets of ranitidine hydrochloride.

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Minimized adverse activity at the colon: National Center for Biotechnology InformationU. Skip to main content. The following polymers used in preparations of floating drugs – 8.

Pulsatile Drug Delivery System Thesis

One of such difficulties is the ability to confine the dosage form in the desired area of the gastrointestinal tract. A bi-layer tablet contain two layer one immediate release layer which releases initial dose from Non-effervescent systems system while the another sustained release layer absorbs gastric fluid, forming an impermeable colloidal gel barrier on its The Non-effervescent FDDS is based on surface, and maintain a bulk density of less than unity and mechanism of swelling of polymer or bioadhesion to thereby it remains buoyant in the stomach.

Conclusions Core In cup pulsatile drug delivery system of metoprolol tartarate is formulated to increase the therapeutic effectiveness of the drug. By Zubair Khalid Labu.

floating pulsatile drug delivery system thesis

Water soluble drugs are mainly released by diffusion; while for water insoluble drug, the release is dependent on dissolution of drug Rdug W et al. The size can also be The following approaches have been used for the design of floating measured using an optical microscope. The axial thickness expansion is also measured in SA1 the initial thickness is 5. Water uptake was 7. SA1 achieved maximum swelling of Journal of Current Pharmaceutical Research ;7 1: The formulation contains three components a core table, impermeable layer and soluble hydrophilic polymer layer.

The lag time obtained in SA1 is 2.