Clinical and histopathological patterns. Results A total of cases were retrieved and reviewed in this study. Nevertheless no noteworthy association between size and duration of growth and the presence of malignancy was found. J Clin Endocrinol Metab. Evaluation of non-palpable thyroid nodules by ultra sound guided fine needle aspiration cytology. Role of ultrasonography in the diagnosis and management of thyroid cancer.
Puncture of Goitres for aspiration biopsy. Although none of the sonographic properties have a reliable and sufficient sensitivity, specificity, positive predictive value PPV and negative predictive value NPV in ascertaining malignancy of the nodules, the sonographic features of the nodules can assists in selecting the nodules for needle aspiration 7 , 9. Distinct effects on splicing of two monoclonal antibodies directed against the amino-terminal domain of galectin To correlate these factors in order to make diagnosis of malignant thyroid swellings in patients more accurate. Duration of symptoms in weeks, Median IQR. The methods used for the calculation of sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were similar to previous studies [ 11 , 12 ].
Conflict of interests The authors declare no conflict of interests. The paraffin wax embedded tisssue specimens were sliced into very thin sections of 3—10 microns thick. None of the tumor revealed the histology of anaplastic or medullary carcinoma. On clinical evaluation, the symptoms suggestive of malignancy were pressure symptoms and lymph node enlargement.
The Bethesda system for reporting thyroid cytopathology. Objectives To estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard. For a rare disease thyroid cancer is relatively uncommonspecificity is the most desirable so that when the test result is negative then chances are very high that the individual has no disease.
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
The follicular thyroid carcinomas also demonstrated the positive expression of Galectin-3 by immunohistochemistry but much less as compared to PTC. In the FNAC technique, equipment involved glass slides, cover slips, antiseptics, disposable gloves, fixative absolute ethyl alcohol ,swabs, 23 French Fr gauge hypodermic needles 23Fr, 24Fr, 25 Fr is recommended and 10 ml syringes.
Baseline clinical characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm. Histopathology is gold standard for confirmation of the diagnosis of malignancy post operatively.
An accurate and finer technique that can be implicated to thyroid nodules being planned for excision is the detection of these immunomarkers on cytology specimens by immunocytology. The authors appreciate the co-operation of patients who participated in tyesis study, the staff from the records section of Pathology Department for retrieving patients’ data and Dr. We found a sensitivity of The thyroid nodule was immobilised and stabilised between the index finger and the thumb of the left hand.
The incidence of higher number of papillary carcinoma than follicular carcinoma is correspondent with other excerpts in the literature.
For a rare disease thyroid cancer is relatively uncommonspecificity is the most desirable so that when the test result is negative then chances are very high that the individual has no disease. Quality control was assured by maintaining that FNB procurement, processing and reporting was done by experienced cytopathologists using the Bethesda system for reporting thyroid cytopathologythe histopathologist examining excised thyroid specimens was blinded to preoperative diagnosis with FNAC and the cytopathologists and histopathologists for FNAC and histopathology of excised specimens respectively were generally the same for both the retrospective and prospective arms of the study thus minimizing inter-observer bias.
The use of a combination of galectin-3 and thyroid peroxidase for the diagnosis and prognosis of thyroid cancer. Sixty cases of solitary thyroid nodules were included in the study.
To study the radiological findings of these patients. Kobusingye found malignancy rate of East African Medical Journal.
Journal List Afr Health Sci v. East African Medical Journal.
Journal of Thyroid Research
Puncture of Goitres for aspiration biopsy. Discussion The aim of tbesis study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard. A 23Fr gauge needle attached to a 10 ml syringe was inserted into the nodule. Nevertheless its sensitivity in differentiating malignant from benign thyroid neoplasms is somewhat less. This provided rigid support to tissue blocks so that it was easy to cut them into thin sections.
With a thyroiv swab, pressure was applied over the biopsy site for about five minutes. A total of 99 patients were enrolled 45 prospective and 54 retrospective. The introduction of the new simplified Bethesda system for reporting Thyroid cytopathology into six categories logically relates to the prognosis of thyroid diseases and increases the reproducibility of diagnosis.
This article has been cited by other articles in PMC. None, Conflict of Thesid More than half i.